歯科治療で認知症を予防する

従来からしっかりかむことにより脳血流が増えることや慢性の歯周炎によって
血管炎が引き起こされて脳梗塞や心筋梗塞につながることは報告されてきました 
しかし近年 歯が抜けることによってアルツハイマー病など認知症になる危険性が
4倍から10倍になるという報告が出てきています これは国内だけでなく世界中
各国で見られている現象です
歯が抜けたら入れ歯でよい、見た目さえ整えばよいと歯科治療は軽視されがちですが 
歯を粗末に扱うことが老後そして高齢化社会に大きな影響を及ぼすことが
改めて認識できたショッキングなデータです
我々もしっかり予防治療に取り組まなければならないと
気持ちを引き締めさせられました

以下に英文の抄録を貼っておきます

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Potentially modifiable risk factors for dementia in identical twins

M James A. Mortimerc, Laura Fratiglionid, Boo Johanssone, Stig Bergaf, Chandra A. Reynoldsg, Nancy L. Pedersenab

Abstract

Background

The purpose of this study was to test nongenetic factors that might explain discordance for dementia in monozygotic twin pairs. Risk factors included education, engaged lifestyle in midlife, and early life circumstances indexed by toothloss, short adult height, and parental social class.

Methods

Data are from the HARMONY study, including members of the Swedish Twin Registry age 65 and older and alive in 1998, who were screened and assessed clinically for dementia. Analyses included a case-control design to evaluate the risk factors and a co-twin control design that permits testing nongenetic risk factors while controlling for genetic influences. Case-control analyses included 310 dementia cases and 3,063 nondemented controls. There were 106 monozygotic twin pairs discordant for dementia. Risk factors were assessed independently by the Swedish Twin Registry three decades previously.

Results

Case-control findings showed that history of toothloss before age 35 and low educational attainment were significant risk factors for Alzheimer’s disease, with short adult height also contributing to risk for total dementia. In co-twin control analyses, only history of toothloss before age 35 was a significant risk factor for Alzheimer’s disease, whereas low educational attainment also contributed to risk for total dementia and lack of physical exercise to risk for non-Alzheimer’s dementias.

Conclusions

Potentially modifiable risk factors from early and midlife, with a cumulative detrimental effect on the brain, contribute to risk of dementia. Based on the association with toothloss, further investigation of inflammatory load as a risk factor for Alzheimer’s disease is warranted.

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